| Pair Name | Celastrol, Docetaxel | ||
| Phytochemical Name | Celastrol (PubChem CID: 122724 ) | ||
| Anticancer drug Name | Docetaxel (PubChem CID: 148124 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Celastrol, Docetaxel | |||
| Disease Info | [ICD-11: 2C60] | Breast cancer | Investigative | |
| Biological Phenomena | Inhibition-->Cell metastasis | |||
| Gene Regulation | Down-regulation | Expression | CBLL1 | hsa79872 |
| Up-regulation | Expression | CDH1 | hsa999 | |
| In Vitro Model | MDA-MB-231 | Breast adenocarcinoma | Homo sapiens (Human) | CVCL_0062 |
| MDA-MB-468 | Breast adenocarcinoma | Homo sapiens (Human) | CVCL_0419 | |
| Result | Our results showing anti-migratory/anti-invasive effects of celastrol and associated mechanisms provide new evidence for the development of celastrol as a potential anti-metastatic compound against highly aggressive breast cancer, and celastrol in combination with docetaxel might potentially be used as a novel regimen for the treatment of TNBC. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Celastrol inhibits the migration and invasion and enhances the anti-cancer effects of docetaxel in human triple-negative breast cancer cells. Med Oncol. 2022 Sep 7;39(12):189. doi: 10.1007/s12032-022-01792-y. | Click |
